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font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* Author&#039;s [https://www.youtube.com/channel/UCLZULfm7l2dZFyDdhrROJKg YouTube Channel]</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* Author&#039;s [https://twitter.com/topfitafter50/ Twitter account]</ins></div></td></tr> <!-- diff cache key thijsklompma-mediaw_:diff::1.12:old-5936:rev-5942 --> </table> RRM http://www.waiwiki.org/index.php?title=Heterocyclic_Amines_(HCA)&diff=5936&oldid=prev RRM: /* Neuro-active HCAs; natural ones and in cooked foods */ 2017-01-26T18:04:28Z <p>‎<span dir="auto"><span class="autocomment">Neuro-active HCAs; natural ones and in cooked foods</span></span></p> <table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 18:04, 26 January 2017</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l99" >Line 99:</td> <td colspan="2" class="diff-lineno">Line 99:</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Neuro-active HCAs; natural ones and in cooked foods==</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Neuro-active HCAs; natural ones and in cooked foods==</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[https://www.instagram.com/topfitafter50/ [Image:Instagram.jpg|thumb|right| <del class="diffchange diffchange-inline">[Author&#039;s Instagram account]]</del>]</div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[https://www.instagram.com/topfitafter50/ [Image:Instagram.jpg|thumb|right|]</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Image:YouTube.jpg|thumb|right| [https://www.youtube.com/channel/UCLZULfm7l2dZFyDdhrROJKg Author&#039;s YouTube channel]]]</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Image:YouTube.jpg|thumb|right| [https://www.youtube.com/channel/UCLZULfm7l2dZFyDdhrROJKg Author&#039;s YouTube channel]]]</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <!-- diff cache key thijsklompma-mediaw_:diff::1.12:old-5935:rev-5936 --> </table> RRM http://www.waiwiki.org/index.php?title=Heterocyclic_Amines_(HCA)&diff=5935&oldid=prev RRM: /* Neuro-active HCAs; natural ones and in cooked foods */ 2017-01-26T18:03:46Z <p>‎<span dir="auto"><span class="autocomment">Neuro-active HCAs; natural ones and in cooked foods</span></span></p> <table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 18:03, 26 January 2017</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l99" >Line 99:</td> <td colspan="2" class="diff-lineno">Line 99:</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Neuro-active HCAs; natural ones and in cooked foods==</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Neuro-active HCAs; natural ones and in cooked foods==</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[Image:Instagram.jpg|thumb|right| [<del class="diffchange diffchange-inline">https://www.instagram.com/topfitafter50/ </del>Author&#039;s Instagram account]]]</div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[<ins class="diffchange diffchange-inline">https://www.instagram.com/topfitafter50/ </ins>[Image:Instagram.jpg|thumb|right| [Author&#039;s Instagram account]]]</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Image:YouTube.jpg|thumb|right| [https://www.youtube.com/channel/UCLZULfm7l2dZFyDdhrROJKg Author&#039;s YouTube channel]]]</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Image:YouTube.jpg|thumb|right| [https://www.youtube.com/channel/UCLZULfm7l2dZFyDdhrROJKg Author&#039;s YouTube channel]]]</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> </table> RRM http://www.waiwiki.org/index.php?title=Heterocyclic_Amines_(HCA)&diff=5934&oldid=prev RRM: /* Neuro-active HCAs; natural ones and in cooked foods */ 2017-01-26T17:44:00Z <p>‎<span dir="auto"><span class="autocomment">Neuro-active HCAs; natural ones and in cooked foods</span></span></p> <table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 17:44, 26 January 2017</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l99" >Line 99:</td> <td colspan="2" class="diff-lineno">Line 99:</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Neuro-active HCAs; natural ones and in cooked foods==</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Neuro-active HCAs; natural ones and in cooked foods==</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Image:Instagram.jpg|thumb|right| [https://www.instagram.com/topfitafter50/ Author&#039;s Instagram account]]]</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Image:YouTube.jpg|thumb|right| [https://www.youtube.com/channel/UCLZULfm7l2dZFyDdhrROJKg Author&#039;s YouTube channel]]]</ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>In the human body (and human milk [http://www.ncbi.nlm.nih.gov/pubmed/2019874]), various endogenous beta-carbolines (eg tetrahydro-beta-carboline (tryptoline), 6-methoxytetrahydro-beta-carboline, tetrahydro-harman, harman, harmalan [http://www.ncbi.nlm.nih.gov/pubmed/3412494][http://www.ncbi.nlm.nih.gov/pubmed/2580722]) act on the Benzodiazepine receptors as neurotransmitters (regulating behavioral habituation [http://www.ncbi.nlm.nih.gov/pubmed/2538132], appetite [http://www.ncbi.nlm.nih.gov/pubmed/2824004] and modulating acetylcholine release [http://www.ncbi.nlm.nih.gov/pubmed/7603619][http://www.ncbi.nlm.nih.gov/pubmed/8298971]), and are monoamine oxidase (MAO) inhibitors [http://www.ncbi.nlm.nih.gov/pubmed/7130973]. beta-Carbolines may be anti-mutagenics, anti-genotoxic [http://www.ncbi.nlm.nih.gov/pubmed/17545209] and often associated with (acetyl)cholinesterase inhibition [http://www.ncbi.nlm.nih.gov/pubmed/22717507][http://www.ncbi.nlm.nih.gov/pubmed/6864229]</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>In the human body (and human milk [http://www.ncbi.nlm.nih.gov/pubmed/2019874]), various endogenous beta-carbolines (eg tetrahydro-beta-carboline (tryptoline), 6-methoxytetrahydro-beta-carboline, tetrahydro-harman, harman, harmalan [http://www.ncbi.nlm.nih.gov/pubmed/3412494][http://www.ncbi.nlm.nih.gov/pubmed/2580722]) act on the Benzodiazepine receptors as neurotransmitters (regulating behavioral habituation [http://www.ncbi.nlm.nih.gov/pubmed/2538132], appetite [http://www.ncbi.nlm.nih.gov/pubmed/2824004] and modulating acetylcholine release [http://www.ncbi.nlm.nih.gov/pubmed/7603619][http://www.ncbi.nlm.nih.gov/pubmed/8298971]), and are monoamine oxidase (MAO) inhibitors [http://www.ncbi.nlm.nih.gov/pubmed/7130973]. beta-Carbolines may be anti-mutagenics, anti-genotoxic [http://www.ncbi.nlm.nih.gov/pubmed/17545209] and often associated with (acetyl)cholinesterase inhibition [http://www.ncbi.nlm.nih.gov/pubmed/22717507][http://www.ncbi.nlm.nih.gov/pubmed/6864229]</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <!-- diff cache key thijsklompma-mediaw_:diff::1.12:old-1225:rev-5934 --> </table> RRM http://www.waiwiki.org/index.php?title=Heterocyclic_Amines_(HCA)&diff=1225&oldid=prev RRM: /* Mutagenic HCA in cooked foods */ 2013-01-15T14:47:06Z <p>‎<span dir="auto"><span class="autocomment">Mutagenic HCA in cooked foods</span></span></p> <table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 14:47, 15 January 2013</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l70" >Line 70:</td> <td colspan="2" class="diff-lineno">Line 70:</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Non-IQ-type HCAs are obtained by heating tryptophan (indoles / gamma-carbolines) or glutamic acid (imidazoles). The actual number of mutagenic HCAs is multiple-fold higher, as for each HCA listed, there may be a serie of mutagenic isomeres. (eg 12 TMIP isomeres[http://www.ncbi.nlm.nih.gov/pubmed/16258923]) &#160;</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Non-IQ-type HCAs are obtained by heating tryptophan (indoles / gamma-carbolines) or glutamic acid (imidazoles). The actual number of mutagenic HCAs is multiple-fold higher, as for each HCA listed, there may be a serie of mutagenic isomeres. (eg 12 TMIP isomeres[http://www.ncbi.nlm.nih.gov/pubmed/16258923]) &#160;</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in broiled sardines, cooked beef, fried fish[http://www.ncbi.nlm.nih.gov/pubmed/6733854], up to levels of 1.9 ng/g in &quot;medium&quot; barbequed sardines.[http://www.ncbi.nlm.nih.gov/pubmed/19265446] IQ is activated to N-hydroxy-2-amino-3-methyl-imidazo[4,5-f]quinoline (N-OH-IQ). Its mutagenicity is distinctly reduced by riboflavin 5&#039;-phosphate (vitamin B2 analog).[http://www.ncbi.nlm.nih.gov/pubmed/10477359] &#160;</div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in broiled sardines, cooked beef, fried fish[http://www.ncbi.nlm.nih.gov/pubmed/6733854], up to levels of 1.9 ng/g in &quot;medium&quot; barbequed sardines.[http://www.ncbi.nlm.nih.gov/pubmed/19265446] IQ is activated to N-hydroxy-2-amino-3-methyl-imidazo[4,5-f]quinoline (N-OH-IQ). Its mutagenicity is distinctly reduced by riboflavin 5&#039;-phosphate (vitamin B2 analog)<ins class="diffchange diffchange-inline">. Vitamin A, K3 and K4 also inhibit IQ induced mutagenesis</ins>.[http://www.ncbi.nlm.nih.gov/pubmed/10477359] &#160;</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* 2-amino-3-methylimidazo[4,5-f]quinoxaline (IQx) in broiled sardines[http://www.ncbi.nlm.nih.gov/pubmed/3276407], grilled beef[http://www.ncbi.nlm.nih.gov/pubmed/15310244], may be metabolized in various (&gt;15), more or less mutagenic derivatives.[http://www.ncbi.nlm.nih.gov/pubmed/7678155]</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* 2-amino-3-methylimidazo[4,5-f]quinoxaline (IQx) in broiled sardines[http://www.ncbi.nlm.nih.gov/pubmed/3276407], grilled beef[http://www.ncbi.nlm.nih.gov/pubmed/15310244], may be metabolized in various (&gt;15), more or less mutagenic derivatives.[http://www.ncbi.nlm.nih.gov/pubmed/7678155]</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* 2-amino-1-methylimidazo[4,5-b]quinoline (IQ[4,5-b]) [http://www.ncbi.nlm.nih.gov/pubmed/15826085] in grilled beef. Also present in urine of vegetarians; may be formed endogenously from creatinine and 2-aminobenzaldehyde.[http://www.ncbi.nlm.nih.gov/pubmed/15777097] &#160;</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* 2-amino-1-methylimidazo[4,5-b]quinoline (IQ[4,5-b]) [http://www.ncbi.nlm.nih.gov/pubmed/15826085] in grilled beef. Also present in urine of vegetarians; may be formed endogenously from creatinine and 2-aminobenzaldehyde.[http://www.ncbi.nlm.nih.gov/pubmed/15777097] &#160;</div></td></tr> <!-- diff cache key thijsklompma-mediaw_:diff::1.12:old-1224:rev-1225 --> </table> RRM http://www.waiwiki.org/index.php?title=Heterocyclic_Amines_(HCA)&diff=1224&oldid=prev RRM: /* HCA inhibitors */ 2013-01-15T14:44:07Z <p>‎<span dir="auto"><span class="autocomment">HCA inhibitors</span></span></p> <table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 14:44, 15 January 2013</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l64" >Line 64:</td> <td colspan="2" class="diff-lineno">Line 64:</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==HCA inhibitors==</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==HCA inhibitors==</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Retinol, retinal, riboflavin, riboflavin 5&#039;-phosphate, FAD, vitamins K1, K3, K4, 1,4-naphthoquinone, and coenzyme Q10 caused a concentration-dependent decrease in the mutagenicity of all six mutagens (IQ, MeIQ, MeIQx, PhIP, Glu-P-1 and Trp-P-2).[http://www.ncbi.nlm.nih.gov/pubmed/10477359]</ins></div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Mutagenic HCA in cooked foods==</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Mutagenic HCA in cooked foods==</div></td></tr> </table> RRM http://www.waiwiki.org/index.php?title=Heterocyclic_Amines_(HCA)&diff=1223&oldid=prev RRM: /* Carcinogenic HCA in cooked foods */ 2013-01-15T14:22:56Z <p>‎<span dir="auto"><span class="autocomment">Carcinogenic HCA in cooked foods</span></span></p> <table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 14:22, 15 January 2013</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l62" >Line 62:</td> <td colspan="2" class="diff-lineno">Line 62:</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Lemon grass inhibits mutagenicity of HCAs.[http://www.ncbi.nlm.nih.gov/pubmed/7523944]</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Lemon grass inhibits mutagenicity of HCAs.[http://www.ncbi.nlm.nih.gov/pubmed/7523944]</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Bacteria from a healthy intestinal microflora may (irreversibly) bind HCAs (50% of PhIP, almost 100% Trp-P-2) [http://www.ncbi.nlm.nih.gov/pubmed/7526189]</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* Bacteria from a healthy intestinal microflora may (irreversibly) bind HCAs (50% of PhIP, almost 100% Trp-P-2) [http://www.ncbi.nlm.nih.gov/pubmed/7526189]</div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&#160;</td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">==HCA inhibitors==</ins></div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Mutagenic HCA in cooked foods==</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Mutagenic HCA in cooked foods==</div></td></tr> </table> RRM http://www.waiwiki.org/index.php?title=Heterocyclic_Amines_(HCA)&diff=1221&oldid=prev RRM: /* Mutagenic HCA in cooked foods */ 2013-01-15T14:11:05Z <p>‎<span dir="auto"><span class="autocomment">Mutagenic HCA in cooked foods</span></span></p> <table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 14:11, 15 January 2013</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l67" >Line 67:</td> <td colspan="2" class="diff-lineno">Line 67:</td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Non-IQ-type HCAs are obtained by heating tryptophan (indoles / gamma-carbolines) or glutamic acid (imidazoles). The actual number of mutagenic HCAs is multiple-fold higher, as for each HCA listed, there may be a serie of mutagenic isomeres. (eg 12 TMIP isomeres[http://www.ncbi.nlm.nih.gov/pubmed/16258923]) &#160;</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Non-IQ-type HCAs are obtained by heating tryptophan (indoles / gamma-carbolines) or glutamic acid (imidazoles). The actual number of mutagenic HCAs is multiple-fold higher, as for each HCA listed, there may be a serie of mutagenic isomeres. (eg 12 TMIP isomeres[http://www.ncbi.nlm.nih.gov/pubmed/16258923]) &#160;</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in broiled sardines, cooked beef, fried fish[http://www.ncbi.nlm.nih.gov/pubmed/6733854], up to levels of 1.9 ng/g in &quot;medium&quot; barbequed sardines.[http://www.ncbi.nlm.nih.gov/pubmed/19265446] &#160;</div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in broiled sardines, cooked beef, fried fish[http://www.ncbi.nlm.nih.gov/pubmed/6733854], up to levels of 1.9 ng/g in &quot;medium&quot; barbequed sardines.[http://www.ncbi.nlm.nih.gov/pubmed/19265446<ins class="diffchange diffchange-inline">] IQ is activated to N-hydroxy-2-amino-3-methyl-imidazo[4,5-f]quinoline (N-OH-IQ). Its mutagenicity is distinctly reduced by riboflavin 5&#039;-phosphate (vitamin B2 analog).[http://www.ncbi.nlm.nih.gov/pubmed/10477359</ins>] &#160;</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* 2-amino-3-methylimidazo[4,5-f]quinoxaline (IQx) in broiled sardines[http://www.ncbi.nlm.nih.gov/pubmed/3276407], grilled beef[http://www.ncbi.nlm.nih.gov/pubmed/15310244], may be metabolized in various (&gt;15), more or less mutagenic derivatives.[http://www.ncbi.nlm.nih.gov/pubmed/7678155]</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* 2-amino-3-methylimidazo[4,5-f]quinoxaline (IQx) in broiled sardines[http://www.ncbi.nlm.nih.gov/pubmed/3276407], grilled beef[http://www.ncbi.nlm.nih.gov/pubmed/15310244], may be metabolized in various (&gt;15), more or less mutagenic derivatives.[http://www.ncbi.nlm.nih.gov/pubmed/7678155]</div></td></tr> <tr><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* 2-amino-1-methylimidazo[4,5-b]quinoline (IQ[4,5-b]) [http://www.ncbi.nlm.nih.gov/pubmed/15826085] in grilled beef. Also present in urine of vegetarians; may be formed endogenously from creatinine and 2-aminobenzaldehyde.[http://www.ncbi.nlm.nih.gov/pubmed/15777097] &#160;</div></td><td class='diff-marker'>&#160;</td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* 2-amino-1-methylimidazo[4,5-b]quinoline (IQ[4,5-b]) [http://www.ncbi.nlm.nih.gov/pubmed/15826085] in grilled beef. Also present in urine of vegetarians; may be formed endogenously from creatinine and 2-aminobenzaldehyde.[http://www.ncbi.nlm.nih.gov/pubmed/15777097] &#160;</div></td></tr> </table> RRM